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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 109331

Časopis

Autori: Sikirić, Predrag; Seiwerth, Sven; Grabarević, Željko; Ručman, Rudolf; Petek, Marijan; Rotkvić, Ivo; Turković, Branko; Jagić, Vjekoslav; Mildner, Boris; Duvnjak, Marko; Danilović, Žarko; Kolega, Marko; Sallmani, Ahmet; Đačić, Sanja; Dodig, Milan; Lang, Nada; Šeparović, Jadranka; Ćorić, Vedran; Šimičević, Velimir; Bulić, Krešimir; Veljača, Marija; Skroza, Nevena; Banić, Marko; Brkić, Tomislav; Buljat, Gojko; Miše, Stjepan; Lučinger, Dražen; Bura, Miljenko
Naslov: Hepatoprotective effect of BPC 157, A 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin
( Hepatoprotective effect of BPC 157, A 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin )
Izvornik: Life Sciences (0024-3205) 53 (1993), 18; 291-296
Vrsta rada: pismo
Ključne riječi: pentadecapeptide BPC 157; liver lesions
( pentadecapeptide BPC 157; liver lesions )
Sažetak:
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct + hepatic artery ligation 48 h-restraint stress and CCl4 administration. BPC 157 administered either intragastrically or intraperitoneally, significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 h bile duct + hepatic artery ligation, 48 h-restraint stress, CCl4 treatment (1 ml/kg i.p., sacrifice 48 h thereafter). The other reference drugs had either little or no protective actions in these models. Noteworthy, the laboratory test results for bilirubin, SGOT, SGPT fully correlated with the macro/microscopical findings. Thus, on the basis of consistent protective eefect of BPC 157, possible clinical application in liver diseases is now warranted.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
URL cjelovitog teksta:
Google Scholar: Hepatoprotective effect of BPC 157, A 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin



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