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Pregled bibliografske jedinice broj: 116905

Časopis

Autori: Hranjec, Marijana; Grdiša, Mira; Pavelić, Krešimir; Boykin, David W.; Karminski-Zamola, Grace
Naslov: Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2, 1-b]furan-carboxylates
Izvornik: Farmaco (0014-827X) 58 (2003), 12; 1319-1324
Vrsta rada: članak
Ključne riječi: synthesis; antitumor activiti; substituted amidino-benzimidazolyl-furyl-phenyl-acrylates; naphtho[2; 1-b]furan-carboxylates
Sažetak:
The multistep synthesis of a series of substituted amidino-benzimidazolyl-furyl-phenyl-acrylic acid`s esters and substituted amidino-benzimidazolyl-naphtho[2, 1-b]furan-carboxylic acid`s esters is described starting from corresponding 3-(2-furyl)-2-phenyl-acrylic acids. The new compounds were tested on the cytostatic activities against malignant cell lines: pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), cervical carcinoma (HeLa), laryngeal carcinoma (Hep2), colon carcinoma (HT 29), melanoma (HBL), and human fibroblast cell lines (WI-38). All compounds inhibited the proliferation of tumor cell lines. Inhibitory effect of examined compounds depended on cencentration, but without significant diference among the type of tumor cells. The compounds 2 and 5 exerted very low inhibitory effect on the growth of human fibroblasts.
Projekt / tema: 0125005, 0098093
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL cjelovitog teksta:
Google Scholar: Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2, 1-b]furan-carboxylates



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