crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 119051

Časopis

Autori: Pavelić, Krešimir; Kolak, Toni; Kapitanović, Sanja; Radošević, Senka; Spaventi, Šime; Krušlin, Božo; Pavelić, Jasminka
Naslov: Gastric cancer: the role of insulin-like growth factor 2 (IGF 2) and its receptors (IGF IR and M6-P/IGF 2R)
Izvornik: Journal of pathology (0022-3417) 201 (2003), 3; 430-438
Vrsta rada: članak
Ključne riječi: insulin-like growth factor 2; IGF 1 receptor; IGF 2 receptor; gastric cancer; autocrine loop; molecularly targeted therapy
Sažetak:
Insulin-like growth factor 2 (IGF 2) appears to be involved in the progression of many tumors. It binds to at least two different types of receptor: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumour suppressor function - it mediates IGF 2 degradation. Mutation of M6-P/1GF 2R causes both diminished growth suppression and augmented growth stimulation. The aim of this study was to investigate the role of IGF2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer. The expression of IGF 2 and its receptors was measured in order to analyse the possible correlation between the activity of these genes and cell proliferation in two different gastric tumour types: diffuse and intestinal. The effect of IGF 1 receptor blockage on cell proliferation and anchorage-independent cell growth was also examined. Increased expression of IGF 2 and IGF 1R genes (at the mRNA and protein level) was found in gastric cancer when compared with nontumour tissue. Furthermore, there was a significant difference between IGF 2 expression in the more aggressive diffuse type and that in the intestinal type of gastric cancer. Moreover, the IGF 2 peptide level in the culture media obtained from the diffuse type of cancer cells was significantly higher when compared with the intestinal type. The level of IGF 2 peptide in the conditioned media strongly correlated with (3H)thymidine incorporation and cell proliferation. On the contrary, IGF 2R mRNA expression was much higher in the intestinal type of cancer than in the diffuse type. In addition, IGF 2R protein expression was substantially lower with progression of the diffuse cancer type to a higher stage. The alphaIR3 monoclonal antibody strongly inhibited (3H) thymidine incorporation and decreased the number of colonies in soft agar of cells overexpressing IGF 2. These findings suggest that members of the IGF family are involved in the pathogenesis of gastric cancer, probably by autocrine/paracrine stimulation of cell growth. Such tumours might be excellent candidates for therapeutic strategies aimed at interference with this pathway.
Projekt / tema: 0134101, 0098092, 0098093, 0098108, 0098109, 0101023, 0098095
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Gastric cancer: the role of insulin-like growth factor 2 (IGF 2) and its receptors (IGF IR and M6-P/IGF 2R)



  Verzija za printanje   za tiskati


upomoc
foot_4