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Pregled bibliografske jedinice broj: 123380

Zbornik radova

Autori: Flegar-Meštrić, Zlata; Vrhovski-Hebrang, Danijela; Juretić, Dubravka; Perkov, Sonja; Preden-Kereković, Vladimira; Hebrang, Andrija; Vidjak, Vinko; Odak, Drago; Grga, Ante; Kosaka, Tetsuya
Naslov: Aktivnost serumske acetil-hidrolaze trombocitnog faktora aktivacije u bolesnika s angiografski utvrđenom cerebrovaskularnom stenozom
Izvornik: Clinical Chemistry and Laboratory Medicine, IFCC-FESCC-EUROMEDLAB Barcelona 2003 / Gerard Siest, Nancy, France (ur.). - Berlin : Walter de Gruyter GmbH and Co. KG. Berlin - New York , 2003. S 421.
Skup: EUROMEDLAB Barcelona 2003: 15th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine 22nd National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology
Mjesto i datum: Barcelona, Španjolska, 1-5.06.2003.
Ključne riječi: biokemijski čimbenici rizika ateroskleroze; ukupni homocistein; ukupni antioksidativni status; visoko osjetljivi C-reaktivni protein; cerebrovascularna stenoza; angiografija
Sažetak:
Oxidation of LDL cholesterol is considered to be one of the key stages in the early development of the atherosclerosis. The platelet-activating factor acetylhydrolase (PAF-AH) seems to have antiatherogenic role as it catabolises oxidized phospholipids on LDL. The aim of this study was to investigate the relation between serum PAF-AH activity in patients with cerebrovascular atherosclerotic changes of different degrees in accordance to the control no-stenosis group. The study comprised 32 patients mean age of 67 years (range 49-80 years) with different degrees of stenosis, established angiographically. The control no-stenosis group consisted of 35 apparently healthy individuals mean age of 55 years (range 44-76 years), with normal cerebral arteries on ultrasound examination. PAF-AH activity was measured with the new automated spectrophotometric assay (AZWELL Auto PAF-AH, Osaka, Japan) on an Olympus AU-600 automatic analyzer (Olympus Mishima Co., Ltd. Shizuoka, Japan). Serum PAF-AH activities did not differ significantly between patient's group with stenosis and the control no-stenosis group (median values 351 U/L versus 380 U/L, >0, 05). Serum PAF-AH activity correlated in control group and the group of patients with total cholesterol (r=0.57 and r=0.56, p<0.05, respectively)and LDL cholesterol (r=0.64 and r=0.48, p<0.05, respectively). The obtained results suggest that serum PAF-AH activity is not associated with cerebrovascular stenosis of different degrees.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0044006
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti



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