Steroid diabetes in children with Crohn disease (CROSBI ID 101537)
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Banac, Srđan ; Peršić, Mladen ; Cvijović, Katarina
engleski
Steroid diabetes in children with Crohn disease
Glucocorticoids may be useful as short-term palliative therapy for acute exacerbations of Crohn disease. When glucocorticoids are used longer than brief periods, even in moderate dosages, they can produce a variety of adverse effects, including steroid diabetes. Two boys were treated with methylprednisolone due to acute exacerbations of Crohn disease. After five and six weeks of continous oral administration of methylprednisolone, the boys developed steroid diabetes. Diabetic symptoms dominated the clinical presentation but there was no tendency towards diabetic ketoacidosis. Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia. Frequent blood glucose monitoring is recommended in children on prolonged therapy with glucocorticoids. Steroid diabetes experienced by reported cases may be a marker for the onset of diabetes in their adulthood.
adverse effects; children; Crohn disease; glucocorticoids; steroid diabetes
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