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Pregled bibliografske jedinice broj: 126262

Časopis

Autori: Frkanec, Ruža; Travaš, Dijana; Krstanović, Marina; Halassy Špoljar, Beata; Ljevaković, Đurđica; Vranešić, Branka; Frkanec, Leo; Tomašić, Jelka
Naslov: Entrapment of peptidoglycans and adamantyltripeptides into liposomes : an HPLC assay for determination of encapsulation efficiency
Izvornik: Journal of liposome research (0898-2104) 13 (2003), 3&4; 279-296
Vrsta rada: članak
Ključne riječi: peptidoglycan monomer; adamantyltripeptides; liposomes; HPLC; encapsulation
Sažetak:
The encapsulation of different immunomodulating peptides, the peptidoglycan monomer, its semisynthetic derivatives (Adamant-1-yl)-acetyl-peptidoglycan monomer and Boc-Tyr-peptidoglycan monomer, respectively, and of two diastereoisomers of adamantyltripeptides into the large negatively charged multilamellar liposomes was investigated. The reproducible quantitative method using HPLC was established for the determination of the entrapped compounds. It was shown that the tested compounds could be efficiently incorporated into liposomes using either the film or modified film method. The results confirmed that the peptidoglycans with lipophilic supstituents and particularly the adamantyltripeptides were incorporated into liposomes with higher efficiency than the peptidoglycan monomer using either of the described methods. Liposome preparations were stable at 4 °C up to seven days as shown by minimal leaking of the entrapped material.
Projekt / tema: 0021002
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://informahealthcare.com/doi/pdf/10.1081/LPR-120026452
http://informahealthcare.com/doi/abs/10.1081/LPR-120026452
Broj citata:
Altmetric:
DOI: 10.1081/LPR-120026452
URL cjelovitog teksta:
Google Scholar: Entrapment of peptidoglycans and adamantyltripeptides into liposomes : an HPLC assay for determination of encapsulation efficiency



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