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Pregled bibliografske jedinice broj: 133555

Časopis

Autori: Vrhovski-Hebrang, Danijela; Flegar-Meštrić, Zlata; Preden-Kereković, Vlatka; Perkov, Sonja; Hebrang, Andrija; Januš, Dragutin; Grga, Ante
Naslov: Biokemijski čimbenici rizika u angiografski utvrđenoj stenozi moždanih arterija
Izvornik: Croatian Medical Journal (0353-9504) 43 (2002), 6; 696-701
Vrsta rada: članak
Ključne riječi: moždane arterije; stenoza; homocistein; lipoprotein(a); čimbenici rizika
Sažetak:
Aim. To determine the significance of the association between biochemical risk factors for cerebrovascular atheroslerosis (lipid parameters, lipoprotein(a), total homocysteine, total antioxidant status, trace elements, and electrolytes) and the degree of stenosis of cerebral arteries scored by digital subtraction angiography. Methods. The study included 35 patients with angiographically established <50% stenosis of cerebral arteries and 55 patients with >50% stenosis of cerebral arteries, including obliteration. The control group consisted of 51 patients with normal cerebral arteries on ultrasound examination. Biochemical parameters were measured in all participants according to the standard laboratory protocols. Results. Logistic regression analysis showed two independent and significant biochemical risk factors associated with the severity of cerebrovascular stenosis: lipoprotein(a) for patients with different degrees of stenosis, and total antioxidant status for patients with severe stenosis of more than 50%. Univariate statistical evaluation showed significantly higher homocysteine levels in the group of patients with >50% stenosis than in the control group (median 14.84 umol/L vs median 12.40 umol/L, p<0.05). Conclusion. Increased lipoprotin(a) and low total antioxidant status values seem to be the most significant independent biochemical risk factors for the development of cerebrovascular stenosis. Mild hyperhomocysteinemia seems to be an additional discriminating indicator of the severe cerebrovascular stenosis. These factors may be useful for early identification and recognition of patients with cerebrovascular atherosclerosis
Projekt / tema: 0044006
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Biokemijski čimbenici rizika u angiografski utvrđenoj stenozi moždanih arterija



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