Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity (CROSBI ID 494795)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Ćaleta, Irena ; Karminski-Zamola, Grace ; Grdiša, Mira ; Pavelić, Krešimir
engleski
Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity
A large number of benzothiazole derivatives are of considerable biological and chemical interest. Their pharmaceutical and agrochemical applications are of particular relevance. In order to find a new biologically active benzothiazole compounds we prepared in the multistep synthesis a serie of new styrylbenzothiazole compounds 1-9 starting from 6-cyano-2-methylbenzothiazole or 2-methylbenzothiazole and corresponding benzaldehydes. Cyano-derivatives of styrylbenzothiazoles 1-3 were converted by Pinner reaction into the corresponding amidine hydrochlorides 4-9. All styrylbenzothiazole compounds were tested on their antitumor activity. All compounds were characterized by means of IR, 1H- and 13C-NMR spectroscopy and elemental analysis.
styrylbenzothiazoles; amidines; biological activity
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Podaci o prilogu
374-374.
2003.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
European simposium on organic chemistry (13 ; 2003)
poster
10.09.2003-15.09.2003
Cavtat, Hrvatska; Dubrovnik, Hrvatska