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Pregled bibliografske jedinice broj: 140683

Časopis

Autori: Šimunić, Velimir; Banović, Ivo; Ciglar, Srećko; Jeren, Lana, Pavičić Baldani, Dinka; Šprem, Marina
Naslov: Local estrogen treatment in patients with urogenital symptoms
( Local estrogen treatment in patients with urogenital symptoms )
Izvornik: International journal of gynaecology and obstetrics (0020-7292) 82 (2003); 187-197
Vrsta rada: članak
Ključne riječi: local estrogen treatment ; efficacy ; safety ; urogenital symptoms
( local estrogen treatment ; efficacy ; safety ; urogenital symptoms )
Sažetak:
Objective was to determine the efficacy and safety of low dose (25  g) micronized 17  -estradiol administered vaginally in the management of patients with urogenital symptoms. A total of 1612 patients with urogenital complaints were randomized to receive 25  g of micronized 17 -estradiol (828) or placebo (784) in a multicentric double-blind placebo controlled study running for 12 months. The women were treated once a day for two weeks, and then twice a week for the rest of the twelve months with the active or placebo tablet. The assessment included full history-questionnaire, micturition diary, gynecological and cystometric examination, transvaginal ultrasound and serum estradiol level determination. It was carried out at the beginning, and after four and twelve months of treatment. The overall success rate of micronized 17 -estradiol on subjective and objective symptoms of postmenopausal women with vaginal atrophy was 85.5%, and the effect of placebo was 41.4%. A significant improvement of urinary atrophy symptoms was determined in vaginal ERT group comparing with the beginning of the study (51.9% vs. 15.5%, p=0.001). Maximal cystometric capacity and the volume of the urinary bladder at which patients first felt urgency and strong desire to void were considerably larger after micronized 17 -estradiol treatment than before it. The number of patients with uninhibited bladder contractions significantly decreased after micronized 17 -estradiol compared with the values before the treatment or after placebo. Side effects were observed in 61 (7.8%) patients treated with low dose micronized 17- estradiol. We found that 25  g of micronized 17- estradiol do not raise serum estrogen level and do not stimulate endometrial growth. Local administration of 25  g of micronized 17- estradiol is effective and safe treatment option in the management of women with urogenital complaints.
Projekt / tema: 0108259
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.ijgo.org/article/S0020-7292%2803%2900200-5/abstract
http://www.sciencedirect.com/science/article/pii/S0020729203002005
Broj citata:
Altmetric:
DOI: 10.1016/S0020-7292(03)00200-5
URL cjelovitog teksta:
Google Scholar: Local estrogen treatment in patients with urogenital symptoms



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