crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 146699

Zbornik radova

Autori: Anđelinović, Deny; Pavelić, Krešimir; Kapitanović, Sanja; Anđelinović, Šimun; Tomić, Snježana; Marasović, Dujomir; Erceg Ivkošić, Ivana; Kuret, Sendi; Franulović, Vesna; Primorac, Dragan
Naslov: Expression of the nm23-H1 gene and loss of heterozygosity in malignant melanoma
Izvornik: 3rd European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine, abstract book / Primorac, Dragan (ur.). - Zagreb : Studio HRG , 2003. .
Skup: 3rd European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine
Mjesto i datum: Zagreb, Hrvatska, 1-5-09.2003.
Ključne riječi: nm23-H1; malignant melanoma
Sažetak:
Nm23-H1 is metastasis suppressor gene that encodes nucleoside diphosphate kinase (NDPK) which plays an important role in metastasis formation of human tumors. In order to investigate its role in the progression of the malignant melanoma we analyzed 51 primary malignant melanoma and eleven melanoma metastases according to the expression level of nm23-H1 and loss of heterozygosity. Nm23-H1 gene instability of 51 melanoma samples compared with normal tissue samples analysed by PCR loss of heterozygosity assay using specific oligonucleotide primers.Thirty three (64, 7%) informative samples were found, among them ten (30, 3%) showed LOH regardless of the Clark and Breslow stage of the malignant melanoma. Ten nm23-H1 protein immunoreactivity was positive in 45 (88, 2%)malignant melanoma samples but no statistically significant correlations between the nm23-H1 expression and Clark's and Breslow's stage were found. In this study eleven primary malignant melanoma showed metastasis. One patient was not informative (homozygous), five patients showed the same fragment length (noLOH) in primary and metastatic malignant cells with the same nm23-H1 expression. In two cases primary tumors turned from noLOH into LOH in metastatic tumors and this was followed by a decrease in the nm23-H1 expression. An association between tumor stage according to Clark and Breslow and nm23-H1 protein levels as well as LOH have not been found in malignant melanoma.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0098108
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti



  Verzija za printanje   za tiskati


upomoc
foot_4