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Pregled bibliografske jedinice broj: 151259

Časopis

Autori: Markotić, Anita; Čikeš Čulić, Vedrana; Tičinović Kurir, Tina; Meisen, Iris; Büntemeyer, Heino; Boraska, Vesna; Zemunik, Tatijana; Petri, Nadan; Peter-Katalinić, Jasna; Mesarić, Marko; Müthing, Johannes
Naslov: Oxygenation alters ganglioside expression in rat liver following partial hepatectomy
Izvornik: Biochemical and biophysical research communications (0006-291X) 330 (2005), 1; 131-141
Vrsta rada: članak
Ključne riječi: HPLC ; HPTLC ; immunostaining ; nanoESI-QTOF mass spectrometry ; sialic acid ; partial hepatectomy ; oxygenation ; gangliosides
Sažetak:
Gangliosides from livers of weanling rats were analysed after 15% partial hepatectomy (PH) and different pre- and post-operative hyberbaric oxygenation (pre- and postHBO). Neu5Ac was the predominant ganglioside-derived sialic acid (>85%) compared to Neu5Gc. Almost identical low total sialic acid content (Neu5Ac+Neu5Gc) of the control and operated nonHBO animals opposed a 6.4 to 7.6 fold increase in pre- and postHBO animals (69.26 and 81.64 pmol per mg wet weight, respectively). NanoESI-QTOF mass spectrometry combined with HPTLC immunostaining revealed GM3(Neu5Ac) and GM3(Neu5Gc) as major gangliosides, correlating with the respective sialic acid concentrations. Minor neolacto- series gangliosides were enhanced in preHBO and postHBO, but GM1-core gangliosides only in preHBO rats. GM2 and GalNAc-GM1b were clearly detectable in oxygenated rats compared to traces in the control and nonHBO animals. These results point at a functional role of gangliosides in liver growth regulation and reconstitution after PH combined with pre- and post-operative HBO treatment.
Projekt / tema: 0216011, 0216013
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0006291X0500416X
Broj citata:
Altmetric:
DOI: 10.1016/j.bbrc.2005.02.139
URL cjelovitog teksta:
Google Scholar: Oxygenation alters ganglioside expression in rat liver following partial hepatectomy



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