engleski

Adamantane derivatives of tenocyclidine : effective radioprotective agent

A slight radioprotective effects of phencyclidine (PCP) and more effectivnes of its adamantilamine derivatives has been found. Many attempts have been done in order to change the chemical structure of PCP mainly by addition of some active groups to its basic structure, to improve its pharmacological properties. Regarding the before mentioned weak radioprotective effect of PCP and reduced toxicity of its adamantylamine derivatives (without sulphur), we prepared tienil phencyclidine (TCP) and three of its adamantil derivatives (with sulphur). We tested in cultured cells to see if this compounds has more radioprotective properties in comparison with PCP and its adamantyl derivatives or than the basic structure of TCP. The results with cells in the present paper show that the piperidine derivative of adamantyl phencyclidine, has rather outstanding radioprotective properties. This derivative revealed significant radioprotection at all survival levels.

adamantane

nije evidentirano