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Pregled bibliografske jedinice broj: 1548

Časopis

Autori: Kralj, Marijeta; Kojić-Prodić, Biserka; Banić, Zrinka; Grdiša, Mira; Vela, Vanja; Šušković, Božidar; Pavelić, Krešimir
Naslov: Synthesis, structural characterization and cytotoxic effect of 6-amino-6-deoxy-L-ascorbic acid derivatives
Izvornik: European journal of medicinal chemistry (0223-5234) 31 (1996), 1; 23-35
Vrsta rada: članak
Ključne riječi: ascorbic acid derivatives ; synthesis ; modelling ; X-ray structure analysis ; cytotoxic effect
Sažetak:
The synthesis, extended molecular modelling and cytotoxic effects of 6-amino-6-deoxy-l-ascorbic acid derivatives are described. For structure—function considerations, comparative conformational analysis was performed and X-ray structure analysis, molecular mechanics and molecular dynamics simulations were used in the search for the bioactive conformation(s). The cytotoxic effect of N, N-dimethyl-6-amino-6-deoxy-l-ascorbic acid on human tumour cell lines (Hep2, MiaPaCa2, HeLa) and on diploid human fibroblast (WI 38) was examined. The dimethylamino derivative of ascorbic acid expressed a stronger cytotoxic effect than ascorbic acid itself. This effect was cell-specific and dose dependent. The treatment of the cells with N, N-dimethyl-6-amino-6-deoxy-l-ascorbic acid probably resulted in apoptosis, evidenced by characteristic morphological changes and ladder DNA fragmentation. Apoptosis was not mediated by c-Myc or p53 proteins.
Projekt / tema: 00980608
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: https://www.sciencedirect.com/science/article/pii/S0223523496800031
Broj citata:
Altmetric:
DOI: 10.1016/S0223-5234(96)80003-1
URL cjelovitog teksta:
Google Scholar: Synthesis, structural characterization and cytotoxic effect of 6-amino-6-deoxy-L-ascorbic acid derivatives



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