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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 156132

Časopis

Autori: Barbarić, Monika; Uršić, Stanko; Pilepić, Viktor; Zorc, Branka; Hergold-Brundić, Antonija; Nagl, Ante; Grdiša, Mira; Pavelić, Krešimir; Snoeck, Robert; Andrei, Graciela; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Naslov: Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids
Izvornik: Journal of medicinal chemistry (0022-2623) 48 (2005); 884-887
Vrsta rada: članak
Ključne riječi: hydroxamic acids; cytostatic evaluation; antiviral evaluation; crystalography
Sažetak:
In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrates that the compounds 2b, d, e and g exhibited rather marked inhibitory activity (IC50 = 7-10 uM) against malignant tumor cell lines: colon carcinoma (SW620), laryngeal carcinoma (Hep2), pancreatic carcinoma (MiaPaCa2). Compound 2e showed the most pronounced anti-CMV activity (EC50 = 1.5 and 0.8 ug mL-1) only at ≥ 5-fold lower than the cytotoxic concentration. Compounds 2d and 2f showed modest, albeit selective activity against cytomegalovirus (2d: EC50 = 7.3-8.9 ug mL-1, selectivity index 7-10, and 2f: EC50 = 7-13 ug mL-1 and selectivity index 10).
Projekt / tema: 0098093, 0006431, 0006543, 0125003
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL cjelovitog teksta:
Google Scholar: Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids



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