The consequences of insulin-like growth factors/receptors dysfunction in lung cancer (CROSBI ID 107078)
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Podaci o odgovornosti
Pavelić, Jasminka ; Križanac, Šimun ; Kapitanović, Sanja ; Pavelić, Ljubomir ; Samaržija, Miroslav ; Pavičić, Fadila ; Spaventi, Šime ; Jakopović, Marko ; Herceg-Ivanovi, Zlata ; Pavelić, Krešimir
engleski
The consequences of insulin-like growth factors/receptors dysfunction in lung cancer
The aim of this study was to investigate the consequences of IGFs/IGF receptors dysfunction in lung carcinomas. A correlation between increased expression (at mRNA and protein levels) for both, IGF 1 and IGF 1R, and decreased apoptosis rate was found in large cell carcinomas and adenocarcinomas. In both tumor types mutations in M6P/IGF 2R gene were also found. The findings suggest that disturbation of the IGFs/IGF receptors axis is involved in lung cancer formation.
insulin-like growth factors; lung cancer
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