crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 158456

Časopis

Autori: Kralj, Marijeta; Kraljević, Sandra; Sedić, Mirela; Kurjak, Asim; Pavelić, Krešimir
Naslov: Global approach to perinatal medicine: functional genomics and proteomics
Izvornik: Journal of perinatal medicine (0300-5577) 33 (2005), 1; 5-16
Vrsta rada: pregledni rad
Ključne riječi: biomarkers; two-dimensional electrophoresis; DNA microarrays; functional genomics; mass spectrometry; perinatal medicine; pre-eclampsia; preterm labor; proteomics; transcriptomics
Sažetak:
Functional genomics (transcriptomics and proteomics) is a global, systematic and comprehensive approach to identification and description of the processes and pathways involved in the normal and abnormal physiological states. The most applied methods of functional genomics today are DNA microarrays and proteomics methods, primarily two-dimensional gel electrophoresis coupled with mass spectrometry. Up to date interesting research have been carried out, representing the milestones for future implementation of functional genomics/proteomics in perinatal medicine. For instance, possible biomarkers of pre-eclampsia, preterm labor and gestational trophoblastic diseases have been discovered. Still, further systematic examination of differentially regulated genes and proteins in maternal and fetal tissues and fluids will be required. However, high-throughput technologies reflect biological fluctuations and methodological errors. Large amount of such different data challenges the performance and capacity of statistical tools and softwares available at the moment. Yet, further major developments in this field are pending and the intellectual investment will certainly result in clinical advances.
Projekt / tema: 0098092, 0098093, 0129008
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Global approach to perinatal medicine: functional genomics and proteomics



  Verzija za printanje   za tiskati


upomoc
foot_4