crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 162710

Časopis

Autori: Kowanetz, Katarzyna; Husnjak, Koraljka; Holler, Daniela; Kowanetz, Marcin; Soubeyran, Philippe; Hirsch, Dianne; Schmidt, H.H. Mirko; Pavelić, Krešimir; De Camilli, Pietro; Randazzo, A. Paul; Dikic, Ivan
Naslov: CIN85 Associates with Multiple Efforts Controlling Intracellular Trafficking of Epidermal Growth Factor Receptors
Izvornik: Molecular biology of the cell (1059-1524) 15 (2004); 3155-3166
Vrsta rada: članak
Ključne riječi: CIN85; Cbl; EGFR; receptor downregulation
Sažetak:
CIN85 is a multidomain adaptor protein involved in Cbl-mediated down-regulation of epidermal growth factor (EGF) receptors. CIN85 src homology 3 domains specifically bind to a proline-arginine (PxxxPR) motif in Cbl, and this association seems to be important for EGF receptor endocytosis. Here, we report identification of novel CIN85 effectors, all containing one or more PxxxPR motifs, that are indispensable for their mutual interactions. These effectors include phosphatidyl-inositol phosphatases SHIP-1 and synaptojanin 2B1, Arf GTPase-activating proteins ASAP1 and ARAP3, adaptor proteins Hip1R and STAP1, and a Rho exchange factor, p115Rho GEF. Acting as a molecular scaffold, CIN85 clusters its effectors and recruits them to high-molecular-weight complexes in cytosolic extracts of cells. Further characterization of CIN85 binding to ASAP1 revealed that formation of the complex is independent on cell stimulation. Overexpression of ASAP1 increased EGF receptor recycling, whereas ASAP1 containing mutated PxxxPR motif failed to promote this event. We propose that CIN85 functions as a scaffold molecule that binds to numerous endocytic accessory proteins, thus controlling distinct steps in trafficking of EGF receptors along the endocytic and recycling pathways.
Projekt / tema: 0098093, 0098104
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: CIN85 Associates with Multiple Efforts Controlling Intracellular Trafficking of Epidermal Growth Factor Receptors



  Verzija za printanje   za tiskati


upomoc
foot_4