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Pregled bibliografske jedinice broj: 176266

Časopis

Autori: Lovrić-Benčić, Martina; Sikirić, Predrag; Hanzevački, Jadranka S.; Seiwerth, Sven; Rogić, Dunja; Kušec, Vesna; Aralica, Gorana; Konjevoda, Paško; Batelja, Lovorka; Boban-Blagaić, Alenka
Naslov: Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse
( Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse )
Izvornik: Journal of pharmacological sciences (1347-8613) 95 (2004), 1; 19-26
Vrsta rada: članak
Ključne riječi: Pentadecapeptide BPC157; Big endothelin-1; Doxorubicine-congestive heart failure; Amlodipine; Losartan
( Pentadecapeptide BPC157; Big endothelin-1; Doxorubicine-congestive heart failure; Amlodipine; Losartan )
Sažetak:
Overall, doxorubicine-congestive heart failure (CHF) (male Wistar rats and NMRI mice ; 6 challenges with doxorubicine (2.5 mg/kg, i.p.) throughout 15 days and then a 4-week-rest period) is consistently deteriorating throughout next 14 days, if not reversed or ameliorated by therapy (/kg per day): a stable gastric pentadecapeptide BPC157 (GEPPPGKPADDAGLV, MW 1419, promisingly studied for inflammatory bowel disease (Pliva ; PL 10, PLD-116, PL 14736)) (10 microg, 10 ng), losartan (0.7 mg), amlodipine (0.07 mg), given intragastrically (i.g.) (once daily, rats) or in drinking water (mice). Assessed were big endothelin-1 (BET-1) and plasma enzyme levels (CK, MBCK, LDH, AST, ALT) before and after 14 days of therapy and clinical status (hypotension, increased heart rate and respiratory rate, and ascites) every 2 days. Controls (distilled water (5 ml/kg, i.g., once daily) or drinking water (2 ml/mouse per day) given throughout 14 days) exhibited additionally increased BET-1 and aggravated clinical status, while enzyme values maintained their initial increase. BPC157 (10 microg/kg) and amlodipine treatment reversed the increased BET-1 (rats, mice), AST, ALT, CK (rats, mice), and LDH (mice) values. BPC157 (10 ng/kg) and losartan opposed further increase of BET-1 (rats, mice). Losartan reduces AST, ALT, CK, and LDH serum values. BPC157 (10 ng/kg) reduces AST and ALT serum values. Clinical status of CHF-rats and -mice is accordingly improved by the BPC157 regimens and amlodipine.
Projekt / tema: 0108238, 0108196, 0214200
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.jstage.jst.go.jp/article/jphs/95/1/19/_pdf
Broj citata:
Altmetric:
DOI: 10.1254/jphs.95.19
URL cjelovitog teksta:
Google Scholar: Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse



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