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izvor podataka: crosbi

Synthesis and comparative cytostatic activity of the new N-7 acyclic purine nucleoside analogues with natural N-9 regioisomers (CROSBI ID 112023)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Prekupec, Svjetlana ; Kalokira, Blanka ; Grdiša, Mira ; Pavelić, Krešimir ; De Clercq, Erik ; Mintas, Mladen ; Raić-Malić, Silvana Synthesis and comparative cytostatic activity of the new N-7 acyclic purine nucleoside analogues with natural N-9 regioisomers // Heterocycles, 65 (2005), 4; 787-796. doi: 10.3987/COM-04-10320

Podaci o odgovornosti

Prekupec, Svjetlana ; Kalokira, Blanka ; Grdiša, Mira ; Pavelić, Krešimir ; De Clercq, Erik ; Mintas, Mladen ; Raić-Malić, Silvana

engleski

Synthesis and comparative cytostatic activity of the new N-7 acyclic purine nucleoside analogues with natural N-9 regioisomers

The synthesis of the purine derivatives alkylated at N-7 (2a) and N-9 (2b) with 2-acetoxyethoxymethyl side chain, and chemical transformations of keto to chloro (5a), chloro to thio (6a) at C-6, and amino to fluoro (7a) at C-2 position of the purine ring were described. Structures of compounds were elucidated by analysis of their 1H and 13C NMR spectra, MS spectra and elemental analyses. N-7 Regioisomers (2a-7a) were evaluated for their cytostatic activities and their inhibitory effects were compared with those of the corresponding N-9 isomers. The 2-aminopurin-6-thione derivative (6a) showed the highest cytostatic activity, particularly against murine leukemia (L1210).

Acyclic Purine Nucleoside Analogues ; Biological Evaluation ; 1H and 13C NMR Spectra

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Podaci o izdanju

65 (4)

2005.

787-796

objavljeno

0385-5414

1881-0942

10.3987/COM-04-10320

Povezanost rada

Kemija

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