engleski

Complexation of copper(II) with L-alanine and its N-alkyl derivatives

A series of mono-and di-alkylated L-alaninates as well as their copper(II) complexes were prepared as a model compounds for a superoxidedismutase (SOD-mimetic) activity. Two independent methods (glass electrode potentiometry, GEP and Square wave voltammetry, SWV) were applied in order to determine their concentration stability constants and speciation under the physiological conditions (I=0.15M). The chelates formed by copper(II) and mono- and di-alkylated L-alaninates are less stable (by factor>10) than the parent copper(II) L-alaninates. From a thorough examination of the data obtained a conclusion may be drawn that further lengthening the alkyl chain (diethyl- and more) on nitrogen atom of L-alanine will not essentially change the values of the stability constants of copper(II) complrxes with N-alkylated L-alaninates which was confirmed by the conformational analyses performed on the same compounds.

Copper(II)-N-alkylated L-alaninato complexes; stability constants; potentiometry; voltammetry

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