Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer (CROSBI ID 81734)
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Podaci o odgovornosti
Šturlan, Sanda ; Kapitanović, Sanja ; Kovačević, Duje ; Lukač, Josip ; Spaventi, Šime ; Spaventi, Radan ; Pavelić, Krešimir
engleski
Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer
We examined 36 cases of human sporadic colon carcinoma and corresponding normal tissue samples to evaluate loss of heterozygosity at the APC and DCC tumor suppressor genes loci using restriction fragment length polymorphism polymerase chain reaction and variable nucleotide tandem repeat analysis. Observed informativity was 83% for APC and 75% for DCC. DNA from 6 (20%) of 30 informative tumors exhibited loss of heterozygosity at the APC locus. Loss of heterozygosity at the DCC locus was observed in 7 (26%) of 27 informative tumor DNAs. Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression.
colon cancer; tumor suppressor genes; APC; DCC; loss of heterozygosity
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti