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Pregled bibliografske jedinice broj: 18880

Časopis

Autori: Šturlan, Sanda; Kapitanović, Sanja; Kovačević, Duje; Lukač, Josip; Spaventi, Šime; Spaventi, Radan; Pavelić, Krešimir
Naslov: Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer
Izvornik: Journal of molecular medicine (0946-2716) 77 (1999), 3; 316-321
Vrsta rada: članak
Ključne riječi: Colon cancer; Tumor suppressor genes; APC; DCC; Loss of heterozygosity
Sažetak:
We examined 36 cases of human sporadic colon carcinoma and corresponding normal tissue samples to evaluate loss of heterozygosity at the APC and DCC tumor suppressor genes loci using restriction fragment length polymorphism polymerase chain reaction and variable nucleotide tandem repeat analysis. Observed informativity was 83% for APC and 75% for DCC. DNA from 6 (20%) of 30 informative tumors exhibited loss of heterozygosity at the APC locus. Loss of heterozygosity at the DCC locus was observed in 7 (26%) of 27 informative tumor DNAs. Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression.
Projekt / tema: 00981104, 101751, 134002
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer



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