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izvor podataka: crosbi

Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer (CROSBI ID 81734)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Šturlan, Sanda ; Kapitanović, Sanja ; Kovačević, Duje ; Lukač, Josip ; Spaventi, Šime ; Spaventi, Radan ; Pavelić, Krešimir Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer // Journal of molecular medicine, 77 (1999), 3; 316-321-x

Podaci o odgovornosti

Šturlan, Sanda ; Kapitanović, Sanja ; Kovačević, Duje ; Lukač, Josip ; Spaventi, Šime ; Spaventi, Radan ; Pavelić, Krešimir

engleski

Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer

We examined 36 cases of human sporadic colon carcinoma and corresponding normal tissue samples to evaluate loss of heterozygosity at the APC and DCC tumor suppressor genes loci using restriction fragment length polymorphism polymerase chain reaction and variable nucleotide tandem repeat analysis. Observed informativity was 83% for APC and 75% for DCC. DNA from 6 (20%) of 30 informative tumors exhibited loss of heterozygosity at the APC locus. Loss of heterozygosity at the DCC locus was observed in 7 (26%) of 27 informative tumor DNAs. Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression.

colon cancer; tumor suppressor genes; APC; DCC; loss of heterozygosity

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

77 (3)

1999.

316-321-x

objavljeno

0946-2716

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost