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Synthesis and Antiproliferative Activity of new Amidino-substituted Furanocarboxyanilides

Amidino-substituted amides exhibit various biological activities, such as anti-cancer and anti-bacterial activity [1, 2]. New benzoamidino-substituted furancarboxanilides were prepared by multistep synthesis from corresponding nitriles using Pinner reaction or by direct condensation of corresponding acyl-chlorides with p-amino-N-(isopropyl)benzo-amidine. All prepared compounds were tested on their antiproliferative activities. In addition, their interactions with ds DNA and RNA were studied by spectroscopic titrations and thermal denaturation experiments.

amidino-supstituted furancarboxanilides; antiproliferative activity; DNA binding

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