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Pregled bibliografske jedinice broj: 194849

Časopis

Autori: Zemunik, Tatijana; Markotić, Anita; Marušić, Ana
Naslov: Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells
Izvornik: Biochemistry Moscow (0006-2979) 69 (2004), 5; 513-519
Vrsta rada: članak
Ključne riječi: endothelium; glycosphingolipids; E-selectin; TNF-alpha; immunohistochemistry
Sažetak:
We compared immunohistochemical distribution of glycosphingolipids globotriosylceramide (GbOse(3)Cer) and globotetraosylceramide (GbOse(4)Cer) with that of E-selectin on human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor (TNF)-alpha. HUVECs activated by TNF-alpha were characterized by the highest expression of E-selectin and greatest adhesion of HL-60 cells as well compared to stimulation with interleukin-1beta or lipopolysaccharide. HUVECs activated by TNF-alpha also stained intensely with globoside antibodies, especially with the GbOse(3)Cer-directed one, staining being redistributed in a concentration-dependent manner. These results indicate the possible role of GbOse(3)Cer and GbOse(4)Cer in immune effector mechanisms of endothelium such as adhesion.
Projekt / tema: 0216013, 0108181, 0216011
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
Puni text rada: 194849.zemunik_endotel.pdf
URL cjelovitog teksta:
Google Scholar: Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells



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