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Pregled bibliografske jedinice broj: 195632

Časopis

Autori: Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Pokrić, Biserka
Naslov: Molecular Recognition Theory of the complementary (antisense) peptide interactions
( Molecular Recognition Theory of the complementary (antisense) peptide interactions )
Izvornik: Theory in biosciences (1431-7613) 123 (2005), 4; 265-275
Vrsta rada: članak
Ključne riječi: molecular; recognition; antisense; peptide; RNA
( molecular; recognition; antisense; peptide; RNA )
Sažetak:
Molecular Recognition Theory is basedon the finding of Blalock et al. (Biochem. Biophys. Res. Commun. 121 (1984) 203-207 ; Nature Med. I (1995)876-878 ; Biochem. J. 234 (1986) 679-683) that peptides specified by the complementary RNAs bind to each other with higher specificity and efficacy. This theory is investigated considering the interaction of the sense peptides coded by means of messenger RNA (read in 5' -3' direction) and antisense peptides coded in 3' -5' direction. We analysed the hydropathy of the complementary amino acid pairs and their frequencies in 1 0 peptide-receptor systems with verified ligand-receptor interaction. An optimization procedure aimed to reduce the number of possible antisense peptides derived from the sense peptide has been proposed. Molecular Recognition Theory was also validated by an "in vivo" experiment. It was shown that 3' -5' peptide antisense of (X-MSH abolished its cytoprotective effects on the gastric mucosa in rats. Molecular Recognition Theory could be useful method to simplify experimental procedures, reduce the costs of the peptide synthesis, and improve peptide structure modelling.
Projekt / tema: 0098097, 0098059
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Molecular Recognition Theory of the complementary (antisense) peptide interactions



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