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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 196137

Časopis

Autori: Pavelić, Krešimir; Hrašćan, Reno; Kapitanović, Sanja; Karapandža, Nikola; Vraneš, S.; Belicza, Mladen; Krušlin, Božidar; Čabrijan, Tomislav
Naslov: Multiple genetic alterations in malignant metastatic insulinomas
Izvornik: Journal of pathology (0022-3417) 177 (1995), 4; 395-400
Vrsta rada: članak
Ključne riječi: insulinoma ; genetic alterations ; oncogenes
Sažetak:
Proto-oncogenes, growth factors/receptors, and tumour suppressor genes were analysed in malignant metastatic insulinomas. Normal pancreas showed only a moderate immunoreaction for c-myc proto-oncogene and a strong reaction for insulin. Benign insulinomas were slightly or moderately positive for transforming growth factor a (TGF alpha), weakly positive for epidermal growth factor receptor (EGF-R), and strongly positive for c-myc and insulin. In malignant insulinomas, besides a strong immunoreaction for c-myc and TGF alpha, activation of c-K-ras and overexpression of p53 protein were found. Insulin reaction was moderate or strong. Three out of six malignant insulinomas displayed a c-g-ras point mutation at codon 12. All mutations were guanine to cytosine transversion, resulting in amino acid substitution, glycine to arginine. Mutations were present in metastatic insulinomas only. Patients with mutated c-g-ras oncogene had overexpression of p53 protein as well as c-myc and TGF alpha overexpression. Our results support the view that malignant progression is a consequence of more than one genetic lesion and suggest that activation of myc, TGF alpha, and ras genes plays a role in a multistep process of tumour progression, perhaps serving as an initiating event.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: https://onlinelibrary.wiley.com/doi/full/10.1002/path.1711770410
Broj citata:
Altmetric:
DOI: 10.1002/path.1711770410
URL cjelovitog teksta:
Google Scholar: Multiple genetic alterations in malignant metastatic insulinomas



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