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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 196462

Časopis

Autori: Čabrijan, Tomislav; Levanat, Sonja; Pekić, Bosa; Pavelić, Jasminka; Spaventi, Radan; Frahm, Helmut; Zjačić-Rotkvić, Vanja; Goldoni, Vesna; Vrbanec, Damir; Misjak, Mira; Grazio, Simeon; Pavelić, Krešimir
Naslov: The role of insulin-related substance in Hodgkins disease
Izvornik: Journal of cancer research and clinical oncology (0171-5216) 117 (1991), 6; 615-619
Vrsta rada: članak
Ključne riječi: Hodgkins disease ; Insulin-related substance ; Hypoglycaemia ; Autocrine stimulation
Sažetak:
An insulin-related growth-promoting substance was detected in the serum of a patient with Hodgkin's disease who suffered from severe hypoglycaemia, as well as in the supernatant of homogenized spleen tissue of the same patient. Low concentrations of this substance enhanced DNA synthesis of short-term-cultured spleen tumour cells obtained from the same patient, while the addition of anti-insulin antiserum interfered with that effect. Moreover, the preincubation of this insulin-related substance with the anti-insulin antiserum abrogated its stimulatory effect on tumour cell proliferation. Both insulin and the insulin-related substance bound to patients splenocytes to a similar extent. The data suggest that the insulin-related substance, found in this particular case of Hodgkin's disease, plays a role in tumour progression by an autocrine mechanism.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: https://link.springer.com/article/10.1007/BF01613298
Broj citata:
Altmetric:
DOI: 10.1007/BF01613298
URL cjelovitog teksta:
Google Scholar: The role of insulin-related substance in Hodgkins disease



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