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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 196492

Časopis

Autori: Pavelić, Krešimir; Banjac, Željka; Pavelić, Jasminka; Spaventi, Šime
Naslov: Evidence for a role of EGF receptor in the progression of human lung carcinoma
Izvornik: Anticancer research (0250-7005) 13 (1993), 4; 1133-1138
Vrsta rada: članak
Ključne riječi: EGF receptor ; human lung carcinoma
Sažetak:
Sixty-three primary lung carcinomas were examined immunohistochemically for the presence of epidermal growth factor receptors (EGF-R). Of these tumors 35 (55.5 %) were positive for EGF-R. A positive correlation between overexpression of EGF-R, on the one hand, and high metastatic rate, poor tumor differentation and high rate of tumor proliferation, on the other hand, was found. From one tumor with an extremely high amount of EGF-R a primary cell culture was established. The addition of anti-EGF-R serum to this culture decreased cell proliferation. Our results support the evidence for a positive relationship between overexpression of EGF-R and invasiveness, poor differentiation and high growth rate of tumor cells. The blockade of EGF-R with specific antibodies suppressed tumor cell-proliferation, suggesting a role of EGF-R in tumor progression.
Izvorni jezik: ENG
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Current Contents Connect (CCC)
MEDLINE
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SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://europepmc.org/abstract/med/8394672
URL cjelovitog teksta:
Google Scholar: Evidence for a role of EGF receptor in the progression of human lung carcinoma



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