crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 197107

Časopis

Autori: Pavelić, Krešimir; Pećina, Nives; Spaventi, Radan
Naslov: Growth factor and proto-oncogenes in early mouse embryogenesis
Izvornik: The International journal of developmental biology (0214-6282) 35 (1991); 209-214
Vrsta rada: članak
Ključne riječi: growth factor ; proto-oncogenes
Sažetak:
Growth factors and proto-oncogenes play an important role in the regulation of embryonic growth and differentiation as well as in tumorigenesis. Insulin and insulin-like growth factor I (IGF I) are secreted by embryonic tissues during the prepancreatic stage of mouse development. Measurable amounts of these factors were found in 8-to 12-day-old embryos. Embryonic cells derived from 8- to 10-day-old embryos secrete insulin and IGF I in serum-free medium. Relatively high levels of c-myc, c-fos and c-H-ras oncoproteins were also detected in 8-to 12- day- old embryos. Insulin and IGF I, when added to the culture of embryonic cells, stimulate their proliferation. Similar results were obtained in some animal or human tumors. Murine myeloid leukemias and melanoma B 16 secrete a substance immunologically cross reactive with insulin (SICRI) both in vivo and in serum-free media. In culture, the DNA synthesis rate per leukemic or melanoma cells is proportinal to cell density and is reduced by antiinsulin serum in case of leukemic cells. Human hemangiosarcoma secrete IGF I, which also plays a role as an autocrine factor. Purified IGF I efficiently induce c-myc and c-fos mRNA, which is among the earliest events following growth factor stimulation, leadin to mitosis. These results lead us to the conclusion that IGF I and insulin together with oncoproteins sitmulate the growth of embryonic and tumor cells, which, is indirect evidence for a paracrine (or autocrine) type of action.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.ijdb.ehu.es/web/descarga/paper/1814404
http://www.ijdb.ehu.es/web/paper/1814404
URL cjelovitog teksta:
Google Scholar: Growth factor and proto-oncogenes in early mouse embryogenesis



  Verzija za printanje   za tiskati


upomoc
foot_4