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Collagenase derived from human fibrosarcoma is responsible for degradation of basement membranes (CROSBI ID 114174)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Slade, Neda ; Levanat, Sonja ; Spaventi, Šime ; Pavelić, Krešimir Collagenase derived from human fibrosarcoma is responsible for degradation of basement membranes // International journal of experimental pathology, 72 (1991), 6; 715-724

Podaci o odgovornosti

Slade, Neda ; Levanat, Sonja ; Spaventi, Šime ; Pavelić, Krešimir

engleski

Collagenase derived from human fibrosarcoma is responsible for degradation of basement membranes

A collagenase-like enzyme with the ability to degrade the proteins of artificial basement membranes (BM) was isolated from human fibrosarcoma. Secretion of the same peptide was observed from the primary fibrosarcoma cell cultures. This peptide degrades the artificial basement membranes derived from bovine corneal endothelial cells. Using electrophoretic methods it was found that the isolated and partially purified enzyme consists of eight bands of different molecular mass corresponding to the collagenase standard from Cl. histolyticum. Only two bands with molecular masses of 22 000 (pI 5.5) and 63 000 (pI 5.9) degrade BM.

human fibrosarcoma ; collagenase ; invasion

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Podaci o izdanju

72 (6)

1991.

715-724

objavljeno

0959-9673

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost