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Pregled bibliografske jedinice broj: 197227

Časopis

Autori: Pavelić, Krešimir; Baltić, Vladimir; Spaventi, Šime
Naslov: Artificial reversion of acute myeloid leukemia cells into normal phenotype
Izvornik: International journal of biochemistry (0020-711X) 22 (1990), 5; 533-538
Vrsta rada: članak
Ključne riječi: acute myeloid leukemia ; cells
Sažetak:
Induction of tumor cell differentiation could reverse transformed cells into normal, mature cells. Important question is whether these malignant-to-normal reversed cells are really normal ones. We have developed an experimental model based on the examination of three different levels of human acute myeloid leukemia cell properties before and after induction of differentiation: morphological (percentage of undifferentiated blast cells), functional (DNA ploidy, Fc receptors, phagocytic activity, clonogenic assay m soft agar, oxidative metabolism which accompanies phagocytosis in mature granulocytes) and genetical (expression of oncogene p53). Several inducers have been employed: dimethylsulfoxide (DMSO) granulocyte-macrophage colony stimulating factor (GM-CSF) ; tunicamycin, interferon gamma, tumor necrosis factor and lypopolysaccharide. Our results indicate that the reversion of leukemic cells into mature normal ones with some inducers (DMSO, GM-CSF) could be a complete process.
Izvorni jezik: ENG
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bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: https://www.sciencedirect.com/science/article/pii/0020711X90902699?via%3Dihub
Broj citata:
Altmetric:
DOI: 10.1016/0020-711X(90)90269-9
URL cjelovitog teksta:
Google Scholar: Artificial reversion of acute myeloid leukemia cells into normal phenotype



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