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Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis (CROSBI ID 114200)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Spaventi, Radan ; Antica, Mariastefania ; Pavelić, Krešimir Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis // Development (Cambridge), 108 (1990), 491-495

Podaci o odgovornosti

Spaventi, Radan ; Antica, Mariastefania ; Pavelić, Krešimir

engleski

Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis

Growth factors have an important role in the regulation of cell growth, division and differentiation. They are also involved in the regulation of embryonic growth and differentiation. Insulin and insulin-like growth factor I (IGF I) play an important part in these events in the later stages of embryogenesis, when organogenesis is completed. In this study, we are presenting evidence that insulin and IGF I are also secreted by embryonic tissues during the prepancreatic stage of mouse development. We found measurable amounts of insulin and IGF I in 8- to 12-day-old mouse embryos. We also showed that embryonic cells derived from 8-, 9- and 10-day-old mouse embryos secrete insulin, IGF I and/or related molecules. Furthermore, the same growth factors, when added to the culture of 9-day-old mouse embryonic cells, stimulate their proliferation. These results lead to the conclusion that insulin can stimulate the growth of embryonic cells during the period when pancreas is not yet formed, which is indirect evidence for a paracrine (or autocrine) type of action.

Insulin ; IGF I ; mouse embryogenesis

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Podaci o izdanju

108

1990.

491-495

objavljeno

0950-1991

1477-9129

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost