Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes (CROSBI ID 114223)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pavelić, Krešimir ; Despot Slade, Neda ; Levanat, Sonja ; Časl, Tino
engleski
Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes
Human fibrosarcoma cells derived from a patient with multiple metastases extensively degrade artificial basement membranes (BM) and secrete interstitial type of collagenase, a proteolytic enzyme responsible for degradation of type I collagen. Exposure of invasive cell line to TGF β abrogates destruction of BM.TGF β reduces collagenase activity and stimulates specific metalloproteinase inhibitor (TIMP) in invasive tumor cells. We preassume that TGF β could play a protective role in tumor invasion.
transforming growth factor beta ; basement membrane ; fibrosarcoma cells ; collagenase
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
371
1990.
687-692
objavljeno
0177-3593
10.1515/bchm3.1990.371.2.687
Povezanost rada
Temeljne medicinske znanosti