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Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes (CROSBI ID 114223)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavelić, Krešimir ; Despot Slade, Neda ; Levanat, Sonja ; Časl, Tino Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes // Biological Chemistry Hoppe-Seyler, 371 (1990), 687-692. doi: 10.1515/bchm3.1990.371.2.687

Podaci o odgovornosti

Pavelić, Krešimir ; Despot Slade, Neda ; Levanat, Sonja ; Časl, Tino

engleski

Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes

Human fibrosarcoma cells derived from a patient with multiple metastases extensively degrade artificial basement membranes (BM) and secrete interstitial type of collagenase, a proteolytic enzyme responsible for degradation of type I collagen. Exposure of invasive cell line to TGF β abrogates destruction of BM.TGF β reduces collagenase activity and stimulates specific metalloproteinase inhibitor (TIMP) in invasive tumor cells. We preassume that TGF β could play a protective role in tumor invasion.

transforming growth factor beta ; basement membrane ; fibrosarcoma cells ; collagenase

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Podaci o izdanju

371

1990.

687-692

objavljeno

0177-3593

10.1515/bchm3.1990.371.2.687

Povezanost rada

Temeljne medicinske znanosti

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