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Pregled bibliografske jedinice broj: 197369

Časopis

Autori: Pavelić, Krešimir; Vrbanec, Damir; Marušić, Suzana; Levanat, Sonja; Čabrijan, Tomislav
Naslov: Autocrine tumor growth regulation by somatomedin C : an in vitro model
Izvornik: Journal of endocrinology (0022-0795) 109 (1986); 233-238
Vrsta rada: članak
Ključne riječi: autocrine growth factor; somatomedin C; in vitro model
Sažetak:
A human primary hemangiosarcoma was derived from a patient with severe hypoglicemia. Cell line established from that tumor secreted somatomedin C in serum-free culture media. Immunoreactive somatomedin from that media eluted from Sephacryl S-200 in two peaks of 160 000 and 8 000 molecular weights. Similar results were obtained when medium was acidified and chromatographed on Sephadex G-50. Binding of tracer concentrations of 125J-labelled somatomedin C to human haemangiosarcoma cells was much higher than that of 125J-labelled insulin. Half maximal displacement of 125J-labelled somatomedin C binding occurred at an unlabelled somatomedin C concentration of 0.7 nmol/l. Insulin competed with 125J-labelled somatomedin for binding to this receptor, but 150-fold more insulin was required for half-maximal displacement. Somatomedin secreted by human haemangiosarcoma cells and purified from serum-free media strongly stimulated /methyl-3H/thymidineincorporation into the DNA of these cells. Inhibition of somatomedin C secreted by cortisol resulted in the inhibition of tumor cell proliferation but stimulation of somatomedin secretion by human GH stimulated the cell proliferation rate. It appears that production of somatomedin C in human haemangiosarcoma cellsplays a part in the regulation of tumour growth by an autocrine mechanism.
Izvorni jezik: ENG
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Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Autocrine tumor growth regulation by somatomedin C : an in vitro model



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