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Pregled bibliografske jedinice broj: 197373

Časopis

Autori: Pavelić, Krešimir
Naslov: L-ascorbic acid-induced DNA strand breaks and cross links in human neuroblastoma cells
Izvornik: Brain research (0006-8993) 342 (1985), 2; 369-373
Vrsta rada: članak
Ključne riječi: L-ascorbic acid ; DNA strand breaks ; cross links ; neuroblastoma cells
Sažetak:
The effect of high concentrations ofl-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of young nude mice bearing human neuroblastoma with 500 mg/kgl-ascorbic acid for the first 10 days markedly inhibited the growth of tumor mass. As determined by alkaline elution, both DNA strand breaks and DNA cross links were observed in tumor cells treated with 1 × 10−4 Ml-ascorbic acid for 2 h. DNA-DNA and DNA-protein cross links in cells treated withl-ascorbic acid were revealed by the proteinase potassium assay. The results indicated thatl-ascorbic acid can be a very effective and selective agent against human neuroblastoma.
Izvorni jezik: ENG
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bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: https://www.sciencedirect.com/science/article/pii/0006899385911394
Broj citata:
Altmetric:
DOI: 10.1016/0006-8993(85)91139-4
URL cjelovitog teksta:
Google Scholar: L-ascorbic acid-induced DNA strand breaks and cross links in human neuroblastoma cells



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