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Effects of immunosupression or immunostimulation on the growth rate of a lymphoid and of a myeloid leukemia in mice (CROSBI ID 114261)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hršak, Ivo ; Pavelić, Krešimir Effects of immunosupression or immunostimulation on the growth rate of a lymphoid and of a myeloid leukemia in mice // Cancer immunology and immunotherapy, 3 (1977), 1; 43-48. doi: 10.1007/BF00199324

Podaci o odgovornosti

Hršak, Ivo ; Pavelić, Krešimir

engleski

Effects of immunosupression or immunostimulation on the growth rate of a lymphoid and of a myeloid leukemia in mice

The influence of immunosuppression or immunostimulation on the growth rate of a lymphatic and of a myeloid murine leukemia has been investigated in syngeneic host-tumour relation. Immunosuppression by chemotherapy or X-rays, induced before transplantation of leukemia cells, did not change the survival time of the animals. Treatment with the immunosuppressive drug cortisone which is not cytostatic for these leukemias, if instituted after the transplantation of malignant cells, enhanced the growth rate of the lymphatic leukemia. Nonspecific stimulation with Corynebacterium parvum induced resistance to a graft of lymphatic leukemia in a majority of the mice, but only slowed the growth rate of myeloid leukemia, without preventing death. Immunosuppressive treatment, given before C. parvum, completely blocked the induction of resistance, and if given after C. parvum, abolished the established resistance to lymphatic leukemia. Thus, the danger of immunosuppression accompanying chemotherapy may lie in its abrogating the protective effects of nonspecific immunostimulation.

immunosuppression ; immunostimulation ; growth rate ; lymphoid ; myeloid leukemia ; mice

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Podaci o izdanju

3 (1)

1977.

43-48

objavljeno

0340-7004

1432-0851

10.1007/BF00199324

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost