Synthesis and biological evaluation of new 2-amino-substituted benzothiazoles (CROSBI ID 507063)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa
Podaci o odgovornosti
Ćaleta, Irena ; Karminski-Zamola, Grace ; Kralj, Marijeta ; Pavelić, Krešimir
engleski
Synthesis and biological evaluation of new 2-amino-substituted benzothiazoles
Over the past decade development of small molecule Src family kinase inhibitors has been an area of major pharmaceutical interest [1]. A large number of benzothiazole derivatives are of considerable biological and chemical interest [2]. 2-Amino-substituted benzothiazoles are reported as inhibitors of Src family kinases [3]. We prepared in multistep synthesis a series of new 2-amino substituted benzothiazoles 1-8 from 4-aminobenzonitrile. All compounds were characterized by IR, 1H- and 13C-NMR spectroscopy and elemental analysis. [1] J. Das, J. Lin, R. V. Moquin, Z. Shen, S. H. Spergel, et al., Bioorg.&Med. Chem. Lett., 13 (2003) 2145-2149. [2] T. D. Bradshaw, F. G. Stevens, A. D. Westwell, Current Med. Chem., 8 (2001) 203-208. [3] J. Das, R. V. Moquin, J. Lin, C. Liu, A. M. Doweyko, et al., Bioorg.&Med. Chem. Lett., 13 (2003) 2587-2590.
2-amino-substituted benzothiazoles; multistep synthesis; biological activity
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Podaci o prilogu
S253-v.
2005.
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objavljeno
Podaci o matičnoj publikaciji
Scientia Pharmaceutica
Erker, Th. ; Reznicek, G.
Beč: Österreichischen Pharmazeutischen Gesellschaft
0036-8709
Podaci o skupu
Joint Meeting on Medicinal Chemistry
poster
20.06.2005-23.06.2005
Beč, Austrija
Povezanost rada
Kemija