Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Lower Contribution of Factor V Leiden or G200210A mutations to ischemic stroke in patients with clinical risk factors : pair-matched case-control study (CROSBI ID 116306)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Eterović, Davor ; Titlić, Marina ; Čulić, Viktor ; Zadro, Renata ; Primorac, Dragan Lower Contribution of Factor V Leiden or G200210A mutations to ischemic stroke in patients with clinical risk factors : pair-matched case-control study // Clinical and applied thrombosis/hemostasis, 13 (2007), 2; 188-193. doi: 10.1177/1076029606298999

Podaci o odgovornosti

Eterović, Davor ; Titlić, Marina ; Čulić, Viktor ; Zadro, Renata ; Primorac, Dragan

engleski

Lower Contribution of Factor V Leiden or G200210A mutations to ischemic stroke in patients with clinical risk factors : pair-matched case-control study

It was suggested that factor V Leiden and prothrombin G20210A mutations increase the risk of ischemic stroke only in combination with clinical risk factors of arterial ischemic disease. In these studies the controls differed from patients in prevalences of clinical risk factors, which might have produced biased results. The factor V Leiden and prothrombin G20210A mutations were examined by polymerase chain reaction technique in 120 ischemic stroke patients and 120 controls less than 65 years old. Each patient had its own control, tightly matched in clinical risk factors. Odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated from Miettenan's formula. The prevalences of factor V Leiden and prothrombin G20210A mutations in patients were 8.3% (P=0.02) and 7.5% (P=0.04) respectively, and 2.5% for controls for both mutations. All carriers were single heterozygotes. In patients, but not in controls the carriers of either mutation were mostly women and with fewer clinical risk factors for arterial ischemic events. In particular, considering both mutations as a single coagulation deficit, their presence increased the likelihood of ischemic stroke (OR=3.6, 95% CI: 1.4-9.3), especially among women (OR=4.6, 95% CI 1.2-17.8), normotonics (OR=9.2, 95% CI: 1.1-17.8) and those having normal cholesterol (OR=5.9, 95% CI: 1.6-21.2) and triglyceride serum concentrations (OR=4.3, 95% CI: 1.5-12.8). In the studied sample of adult North Mediterranean population younger than 65 years the prevalences of factor V Leiden and prothrombin G20210A mutations were greater in patients with ischemic stroke than in healthy controls, but there was an apparent negative interaction of these mutations with clinical risk factors.

factor V Leiden; G20210A; stroke

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

13 (2)

2007.

188-193

objavljeno

1076-0296

10.1177/1076029606298999

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
Indeksiranost