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Pregled bibliografske jedinice broj: 208116

Časopis

Autori: Katić, Maša; Bošnjak, Berislav; Gall-Trošelj, Koraljka; Đikić, Ivan; Pavelić, Krešimir
Naslov: A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro
Izvornik: Frontiers in bioscience (1093-9946) 11 (2006); 1722-1732
Vrsta rada: članak
Ključne riječi: clinoptilolite; media; cell signaling; apoptosis
Sažetak:
Clinoptilolite is a nontoxic natural zeolite with properties of an ion-exchanger and adsorbent. Earlier studies showed that clinoptilolite could be an adjuvant in cancer therapy. The aim of this study was to define effects of clinoptilolite in cell media in cell viability and activity of key proteins regulating cell survival, cell division and stress response. The number of viable cells, DNA synthesis and activity of EGF-R, PKB/Akt and NF B was reduced, while apoptosis was increased in cells that were cultured in medium supplemneted with clinoptilolite. These results might be due to adsorbtion of some serum components such as EGF to clinoptilolite. In treated medium without serum the predominant role of clinoptilolite is that of cation exchange, likely affecting calcium levels and calcium-dependent signalling pathways. These results are in line with other data that confirm enhanced apoptosis in cells incubated in treated medium. Together, data presented here demonstrate that clinoptilolite affects cellular microenvironment through mechanisms that are dependent on adsorptive and ion-exchange characteristics of this material.
Projekt / tema: 0098093, 0098095
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: A clinoptilolite effect on cell media and the consequent effects on tumor cells in vitro



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