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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 210278

Časopis

Autori: Prekupec, Svjetlana; Makuc, Damjan; Plavec, Janez; Kraljević, Sandra; Kralj, Marijeta; Pavelić, Krešimir; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Raić-Malić, Silvana; Mintas, Mladen
Naslov: Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives
Izvornik: Antiviral chemistry & chemotherapy (0956-3202) 16 (2005); 327-338
Vrsta rada: članak
Ključne riječi: C-6 fluoroalkylated pyrimidine derivatives ; conformational analysis ; antiviral activity ; cytostatic activity ; apoptosis
Sažetak:
A series of the novel 5-methyl pyrimidine derivatives with an acyclic side chain at the C-6 position were synthesized using lithiation of a 2, 4-dimethoxy-5, 6-dimethyl pyrimidine and subsequent nucleophilic addition or substitution reactions of the organolithium intermediate thus obtained with acetaldehyde, epichlorhydrine, fluorinated ketones and fluorinated ester. The novel compounds were evaluated on their cytostatic and antiviral activities. Among all the compounds evaluated, two fluorinated acyclic pyrimidine derivatives showed the highest cytostatic activities. The compound containing a 2-hydroxy-3, 3, 3-trifluoro-1-propenyl side chain exhibited a pronounced effect against breast carcinoma (MCF-7, IC50 = 8.38 ug/ml), while the compound with 1 2-fluoromethyl-2-acetoxypropyl chain exhibited moderate effect against cervical carcinoma (HeLa, IC50 = 19.73 ug/ml).
Projekt / tema: 0098092, 0125003, 0098093
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://www.intmedpress.com/serveFile.cfm?sUID=7e4b916e-5dd9-4435-b734-347f18f03340
http://www.intmedpress.com/journals/avcc/abstract.cfm?id=667&pid=92
Broj citata:
Altmetric:
DOI: 10.1177/095632020501600505
URL cjelovitog teksta:
Google Scholar: Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives



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