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Pregled bibliografske jedinice broj: 217789

Časopis

Autori: Boban-Blagaić, Alenka; Blagaić, Vladimir; Romić, Željko; Jelovac, Nikola; Dodig, Goran; Ručman, Rudolf; Petek, Marijan; Turković, Branko; Seiwerth, Sven; Sikirić, Predrag
Naslov: The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of NG-nitro-L-arginine methyl ester and L-arginine
( The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of NG-nitro-L-arginine methyl ester and L-arginine )
Izvornik: Medical science monitor (1234-1010) 12 (2006), 1; 36-45
Vrsta rada: članak
Ključne riječi: Gastric pentadecapeptide BPC 157; alcohol; acute intoxication; withdrawal; NO-agents
( Gastric pentadecapeptide BPC 157; alcohol; acute intoxication; withdrawal; NO-agents )
Sažetak:
Alcohol disturbances, NO stimulation (by the NO-precursor L-arginine), and/or NO-synthesis blockade (by NG-nitro-L-arginine methyl ester, i.e. L-NAME) were challenged with stable gastric pentadecapeptide BPC 157, which inhibits both acute alcohol intoxication and alcohol withdrawal symptoms. Materials and methods. Mice received intraperitoneally (i.p.) BPC 157 (10 µ ; ; ; ; g/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days. Results. BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures). NO-agents: Aggravation of acute alcohol intoxication and opposition to withdrawal are common, but the later intervals affected by L-arginine and the action throughout the experiment by L-NAME are distinctive. Given together, L-arginine and L-NAME counteract each other, while either the “ L-NAME presentation” (acute intoxication) or the “ L-arginine presentation” (withdrawal) predominates. BPC157+NO-agent: In acute intoxication (L-NAME predominating in NO-system functioning to aggravate intoxication), both BPC157+L-NAME and BPC157+L-arginine follow the presentation of L-NAME, but without worsened mortality. In withdrawal (L-arginine predominating in NO-system functioning to oppose disturbance symptoms), BPC157+L-NAME follows the presentation of L-NAME, while BPC 157+L-arginine imitates that of L-arginine. Conclusion. The relationships among pentadecapeptide BPC 157, the NO-system, acute alcohol intoxication, and opposed withdrawal may be important, presenting pentadecapeptide BPC 157 as a suitable alcohol antagonist.
Projekt / tema: 0108238, 0108196
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of NG-nitro-L-arginine methyl ester and L-arginine



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