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Pregled bibliografske jedinice broj: 220539

Zbornik radova

Autori: Vidović, Anđelko; Vilibić, Maja; Markotić, Alemka; Sabioncello, Ante; Gotovac, Katja; Folnegović-Šmalc, Vera; Dekaris, Dragan
Naslov: Platelet activity in PTSD
( Platelet activity in PTSD )
Izvornik: Abstracts of Annual Meeting 2005 of Croatian immunological society / Jonjić, Stipan (ur.). - Rijeka :
Skup: Annual Meeting of the Croatian Immunological Society 2005
Mjesto i datum: Božava Dugi otok, Hrvatska, 29.09-2.10.2005.
Ključne riječi: posttraumatic stress disorder; PTSD; platelets; aggregates; flow cytometry
( posttraumatic stress disorder; PTSD; platelets; aggregates; flow cytometry )
Sažetak:
The evidence linking exposure to traumatic stress and cardiovascular disease is compelling and is supported by different epidemiologic studies. Platelets play a crucial role in the evolution of acute coronary syndromes and an exaggerated platelet activity has been shown to be associated with a higher incidence of acute coronary events. It is tempting to hypothesize that PTSD (post traumatic stress disorder) may confer a heightened platelet activity. This association might be formed through increased sympathetic output associated with PTSD. To investigate this possibility, we assessed platelet function in 20 Croatian war veterans with PTSD and 19 age matched healthy controls. Whole blood flow cytometry was used to determine percentage of CD63 positive (activated) platelets and percentages of monocyte-, granulocyte- and lymphocyte-platelet aggregates in unlysed, unwashed whole blood. Soluble P-selectin levels will be determined by ELISA in sera of participants. This pilot study showed that there are no differences between studied groups in any of measured parameters. However, as monocyte-platelet aggregates tend to be higher in PTSD patients, we performed the power analysis showing that bigger sample sizes would be needed for such a difference to be significant. Monocyte-platelet aggregates provide very sensitive measurement of platelet function and are susceptible to various confounding factors. It would still remain unclear if difference of this size is of any biological importance.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 0021003
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Puni text rada: 220539.Platelet_activity_in_PTSD_-_HID_2005.pdf



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