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Pregled bibliografske jedinice broj: 2223

Časopis

Autori: Kapitanović, Sanja; Radošević, Senka; Kapitanović, Milan; Anđelinović, Šimun; Ferenčić, Željko; Tavassoli, Mahvash; Primorac, Dragan; Sonicki, Zdenko; Spaventi, Šime; Pavelić, Krešimir; Spaventi, Radan
Naslov: The expression of p185(her-2/neu) correlates with the stage of disease and survival in colorectal cancer
Izvornik: Gastroenterology (0016-5085) 112 (1997), 4; 1103-1113
Vrsta rada: članak
Ključne riječi: growth-factor-receptor; human-breast cancer; neu oncogene; c-erbb-2 oncogene; carcinoma cells; proto-oncogene; gene; protooncogene; amplification; erbb-2
Sažetak:
Background & Aims: HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor that is amplified and/or overexpressed predominantly in adenocarcinomas. This phenomenon has been most intensively studied in breast carcinoma where its amplification and overexpression correlate with the overall course of disease and poor prognosis. This study was designed to investigate HER-2/neu gene expression in benign and malignant colorectal lesions and to evaluate its prognostic importance in colorectal cancer. Methods: Two hundred twenty-one samples of normal colon, benign lesions, and colorectal adenocarcinomas were studied for expression of HER-2/neu oncoprotein. Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections of primary tumor and lymph nodes was performed. Immunoprecipitation followed by Western blotting of freshly frozen samples of the same tumors were also performed. Results: Normal colon mucosa, benign lesions, and adenocarcinomas clearly differed in the expression levels and histological distribution of p185(HER-2/neu). Normal mucosa was mostly negative, but significant number of benign lesions and adenocarcinomas overexpressed HER-2/neu protein. Adenocarcinomas were significantly more positive than benign lesions. The results show significant correlation with the epithelial abnormality degree and clinical parameters including Dukes" classification and relapse-free and postoperative survival period. Conclusions: The p185(HER-2/neu) rate expression could serve as an independent prognostic factor in patients with p185(HER-2)/(neu)-positive colorectal malignancies. [References: 47]
Projekt / tema: 134002, 108194, 101751, 00981104
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Puni text rada: 2223.1997_Gastroenterology_Kapitanovic_The_expression.pdf (tekst priložen 28. Ožu. 2007. u 14:11 sati)
URL cjelovitog teksta:
Google Scholar: The expression of p185(her-2/neu) correlates with the stage of disease and survival in colorectal cancer



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