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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 224438

Časopis

Autori: Novak, Predrag; Tepeš, Predrag; Fistrić, Ines, Bratoš, Igor; Gabelica, Vesna
Naslov: The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid
( The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid )
Izvornik: Journal of Pharamaceutical and Biomedical Analysis (0731-7085) 40 (2006), 5; 1268-1272
Vrsta rada: članak
Ključne riječi: 5-Aminosalicylic acid; Impurity; Liquid chromatography– nuclear magnetic resonance spectroscopy; Liquid chromatography– mass spectrometry
( 5-Aminosalicylic acid; Impurity; Liquid chromatography– nuclear magnetic resonance spectroscopy; Liquid chromatography– mass spectrometry )
Sažetak:
UNCORRECTED PROOF Thiswork has demonstrated the usefulness of combining liquid chromatography- nuclear magnetic resonance spectroscopy (LC- NMR) and liquid chromatography- mass spectrometry (LC- MS) methodologies for a rapid identification of an unknown impurity (N1) in the drug 5-aminosalycilic acid. Complementary information obtained from the two methods has revealed plenty of structural information and led to the fast on-line structure determination of N1 prior to its isolation and purification. The analysis of LC-NMR and LC- MS spectra revealed that N1 and 5-aminosalycilic acid are structurally closely related compounds. The structure of N1was later confirmed by high-resolutionNMRspectroscopy of the isolated compound and the atom assignment was made. The approach described here has potential for 5-aminosalycilic acid impurity profiling and monitoring the production process.
Projekt / tema: 0119641
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL cjelovitog teksta:
Google Scholar: The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid



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