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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 228360

Časopis

Autori: Kosor, Ela; Gagro, Alenka; Draženović, Vladimir; Kuzman, Ilija; Jeren, Tatjana; Čečuk-Jeličić, Esma; Kerhin-Brkljačić, Vesna; Gjenero-Margan, Ira; Kaić, Bernard; Rakušić, Snježana; Sabioncello, Ante; Markotić, Alemka; Rabatić, Sabina; Mlinarić-Galinović, Gordana; Dekaris, Dragan
Naslov: Enumeration of haemagglutinin-specific CD8+ T cells after influenza vaccination using MHC class I peptide tetramers
( Enumeration of haemagglutinin-specific CD8+ T cells after influenza vaccination using MHC class I peptide tetramers )
Izvornik: Scandinavian journal of immunology (0300-9475) 67 (2007), 1; 86-94
Vrsta rada: članak
Ključne riječi: influenza; vaccine; MHC class I tetramers; CD8+ T cells
( influenza; vaccine; MHC class I tetramers; CD8+ T cells )
Sažetak:
With emergence of MHC class I tetramers loaded with CD8+ T-cell viral epitopes, it is possible to study virus-specific CD8 cells in humans during infection and after vaccination. MHC class I tetramers was used to detect the frequency of haemagglutinin (HA)-specific T cells in 26 healthy influenza-vaccinated humans. Peripheral blood was collected before, and 7, 14 and 28 days after vaccination. Four-colour flow cytometry was used for monitoring of vaccine induced T-cell response. In 15 donors, two- to fivefold increase in frequency of HA-specific T cells was observed 7 days after vaccination. In addition, in 12 of these donors, this increase was accompanied with fourfold increase of H1N1 antibody titre. The increase in frequency of HA-specific CD8+/IFN-gamma+ cells was low and peaked 28 days after vaccination in three of the six donors tested. Frequencies of HA-specific CD8+ T cells and antibody titre returned to prevaccination values 1 year after vaccination. Subunit influenza vaccines have the ability to induce HA-specific CD8+ cells. As the immune response to this vaccine decreased significantly after 1 year, our results confirm the importance of annual immunization for adequate protection.
Projekt / tema: 072-1080229-0337, 021-0212432-2434, 143-1430115-0103
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www3.interscience.wiley.com/cgi-bin/fulltext/119401948/PDFSTART
Broj citata:
Altmetric:
DOI: 0.1111/j.1365-3083.2007.02042.x
URL cjelovitog teksta:
Google Scholar: Enumeration of haemagglutinin-specific CD8+ T cells after influenza vaccination using MHC class I peptide tetramers
Napomene:
Dio istraživanja opisanih u radu financiran je i sredstvima projekta TP-01/0021-05 (voditelj Alenka Gagro).



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