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Pregled bibliografske jedinice broj: 228633

Časopis

Autori: Punda, Ante; Polić, Stojan; Rumboldt, Zvonko; Bagatin, Jugoslav; Marković, Vinko; Lukin, Ajvor
Naslov: Effects of atenolol and propranolol on platelet aggregation in moderate essential hypertension: randomized crossover trial
( Effects of atenolol and propranolol on platelet aggregation in moderate essential hypertension: randomized crossover trial )
Izvornik: Croatian Medical Journal (0353-9504) 46 (2005), 2; 219-224
Vrsta rada: članak
Ključne riječi: atenolol; propranolol; platelet aggregation
( atenolol; propranolol; platelet aggregation )
Sažetak:
aggregation. METHODS: Twenty successive outpatients with moderate essential hypertension (6 women and 14 men, mean age-/+standard deviation 42.6-/+8.5 years) were randomized to either propranolol (40 mg three times a day) or atenolol (100 mg once a day) for the first two weeks, followed by a one-day washout period, and then a two-week administration of the alternative drug. Along with standard examinations and tests, circulating platelet aggregates were measured. RESULTS: There were no significant differences in creatinine, blood glucose, potassium, total cholesterol, hemoglobin, red blood cells (RBC), or platelets in three periods: baseline, atenolol, and propranolol period. Significant and comparable reductions in systolic and diastolic arterial pressure, body weight, heart rate, and HDL-cholesterol were recorded in both patient groups. The LDL-cholesterol concentration increased significantly in propranolol compared with both baseline and atenolol period. Serum triglycerides increased significantly with both medications. The number of circulating platelet aggregates decreased significantly with propranolol (0.99-/+0.19) in comparison with both atenolol (1.41-/+0.70 ; P=0.004, Wilcoxon matched pairs test) and baseline (1.59-/+0.94 ; P=0.002, Wilcoxon matched pairs test). CONCLUSION: Propranolol inhibits platelet aggregation more than atenolol and may have a favorable effect on the management of hypertension especially in patients with increased cardiovascular risk.
Projekt / tema: 0141011
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Effects of atenolol and propranolol on platelet aggregation in moderate essential hypertension: randomized crossover trial



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