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Pregled bibliografske jedinice broj: 251990

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Autori: Petrović, Igor; Dobrić, Ivan; Drviš, Petar; Shejbal, Dražen; Batelja, Lovorka; Brčić, Luka; Boban Blagaić, Alenka; Kokić, Neven; Tonkić, Ante; Miše, Stjepan; Baotić, Tomislav; Starešinić, Mario; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Prolonged esophagitis in rat: Stable gastric pentadecapeptide BPC 157 (PLD116, PL14736, Pliva) relation to critical period for threatening outcome and failure of lower esophageal and pyloric sphincter
( Prolonged esophagitis in rat: Stable gastric pentadecapeptide BPC 157 (PLD116, PL14736, Pliva) relation to critical period for threatening outcome and failure of lower esophageal and pyloric sphincter )
Izvornik: Abstracts of the 12th International Conference on Ulcer Research (ICUR) and GI Satellite of IUPHAR 2006 ; u: Digestion 73 (2006) (S2) 1-74 / Arakawa, Tetsuo (ur.). - Basel : Karger AG , 2006. 48-48.
ISSN: 0012-2823
Skup: International Conference on Ulcer Research and GI Satellite of IUPHAR (12 ; 2006)
Mjesto i datum: Osaka, Japan, 07.-09.07.2006.
Ključne riječi: BPC 157; esophagitis; sphincter pressure; gastroduodenal reflux
( BPC 157; esophagitis; sphincter pressure; gastroduodenal reflux )
Sažetak:
Aim. We focus whether the critical period for threatening outcome in prolonged esophagitis and relation with prolonged failure of lower esophageal sphincter (LES) and pyloric sphincter (PS) could be modified with a stable gastric pentadecapeptide BPC 157 , promising in inflammatory bowel disease (PLD116, PL14736, Pliva). It attenuates esophago-jejunal anastomosis-esophagitis (J Phys, 1999) (1 month), and recovers and maintains esophageal mucosal integrity and sphincters pressure for 1 year (Gastroenterology, 2004) in rats that had grossly intact GI tract with the essential function failure mimicked by tubes into LES and PS. Methods. This procedure induces prominent esophagitis, LES- and PS-malfunction (one tube inserted into LES, and the other tube into PS, for 1 week, then both artlessly removed), gastroduodenal contents reflux. Now, considerably extending esophagitis period, BPC 157 effect was compared in these esophagitis rats with grossly intact GI-tract with essential function failure, after 12 and 20 months, with respect to normal-healthy rats and (i) sphincters pressure (LES, PS) and (ii) esophagitis attenuation. Assessed at 12 or 18 months of esophagitis: (i) LES-, PS- pressure (cm H2O). Water manometer connected with drainage port of Foley catheter was implanted into the stomach either through esophageal or duodenal incision before BPC 157 or saline (1 ml/rat ; 5ml/kg) were given directly into the stomach ; assessment was at 5 min thereafter. (ii) Reflux esophagitis. Macro- (scored 0 (normal) to 4 (the worst)) as well as micro-scopically (program SFORM, VAMSTECH-Software Company, Croatia) ; BPC 157 (10 µ ; g /kg) i.p. once daily or in drinking water. Results. (i) Sphincter pressure. Esophagitis-rats present a marked sphincter dysfunction, constantly lessened LES- and PS-pressure. For both LES and PS, BPC 157 (a) promptly increases the decreased values till the level in healthy, then, (b) maintains pressure preserved at the healthy level during 12-18 months period, while (c) in normal rats, it increases LES- , but decreases PS- pressure (Fig. 1). (ii) Esophagitis-attenuation. BPC 157 attenuates esophageal lesion at either region, and either interval. Thinner epithelium and superficial corneal layer in controls (12-18 months) than in naive healthy and BPC 157 treated animals. Controls (12 months) present a stratification derangement in contrast to healthy controls and BPC treated animals.
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Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0108238
Izvorni jezik: eng
Kategorija: Znanstveni
URL Internet adrese: http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&searchWhat=books&ProduktNr=231969
Napomene:
DOI:10.1159/000093383



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