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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 253062

Časopis

Autori: Dragović, Milan; Hammond, Geoff; Badcock, C. Johanna; Jablensky, Assen
Naslov: Laterality phenotypes in schizophrenia patients, their siblings and control subjects: associations with clinical and cognitive variables
Izvornik: British Journal of Psychiatry (0007-1250) 187 (2005); 221-228
Vrsta rada: članak
Ključne riječi: laterality; schizophrenia; phenotype; cognition; handedness
Sažetak:
Background: Various behavioural indices of brain lateralisation significantly intercorrelate, but current research in this area still focuses on single behavioural asymmetries, such as handedness. Aim: To describe a novel approach, which simultaneously integrates various laterality indices and delineates complex phenotypes. Method Grade of membership (GoM) analysis was used to describe latent, complex lateralisation phenotypes in schizophrenia patients, their siblings and controls. The indices used were: (i) asymmetries of eye, foot and hand ; (ii) hand motor proficiency ; and (iii) handedness of patient’ s first-degree relatives. Results: Three distinct pure types of lateralisation (‘ right’ , ‘ left’ and ‘ mixed’ ) were evident in patients compared to two (‘ right’ and ‘ left’ ) in siblings and controls. The ‘ mixed’ type in patients featured absence of eye and foot lateralisation, and presence of familial sinistrality, despite a right-hand dominance for writing. Patients with schizophrenia expressing the ‘ left’ phenotype had a more severe course of illness, significantly increased scores on two schizotypy factors and poorer neurocognitive performance. The pure types in the siblings were similar to those in healthy controls. Conclusions: The findings suggest that a leftward reversal, rather than a reduction in lateralisation, is associated with clinical severity and neurocognitive deficits in patients with schizophrenia.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Psihologija
URL cjelovitog teksta:
Google Scholar: Laterality phenotypes in schizophrenia patients, their siblings and control subjects: associations with clinical and cognitive variables



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