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Pregled bibliografske jedinice broj: 253101

Zbornik radova

Autori: Dragović, Milan; Jablensky, Assen
Naslov: Laterality phenotypes in schizophrenia patients, their unaffected siblings and controls
Izvornik:
Skup: The Australasian Society for Psychiatric Research
Mjesto i datum: Christchurch, New Zealand, 04-05.12.2003
Ključne riječi: phenotypes; laterality; schizophrenia
Sažetak:
Although behavioural indices of brain lateralisation are intercorrelated, current research in this area still focuses on isolated behavioural asymmetries, such as shift in handedness. Simultaneous integration of various laterality indices to delineate complex phenotypes might be a more productive research approach. In this study we used a version of latent class analysis - the Grade of Membership model - to describe complex lateralisation phenotypes in schizophrenic patients, their unaffected siblings and controls. The selected indices were: eye, foot and hand asymmetries ; motor proficiency ; and putative genetic indicants (parent’ s handedness, sibling’ s handedness, and familial sinistrality). Three “ pure type” lateralisation patterns were derived from schizophrenia patients and their unaffected siblings, as compared to healthy controls, where only two patterns were found. In the group of schizophrenia patients, lateralisation phenotypes (two leftward and one rightward) showed distinct clinical and behavioural profiles. One of the leftward phenotypes in schizophrenia patients displayed greater clinical severity (lower age at onset, frequent hospital admissions, and more antipsychotic medication) and poorer neurocognitive performance (lower current IQ, poorer sustained attention, and slower speed of information processing). The characterisation of pure lateralisation types in unaffected siblings revealed closer phenotypic similarity to schizophrenia patients, than to controls, thus suggesting a possible genetic effect.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Psihologija



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