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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 257998

Časopis

Autori: Mandić, Zoran; Gabelica, Vesna
Naslov: Ionization, lipophilicity and solubility properties of repaglinide
( Ionization, lipophilicity and solubility properties of repaglin )
Izvornik: Journal of pharmaceutical and biomedical analysis (0731-7085) 41 (2006), 3; 866-871
Vrsta rada: članak
Ključne riječi: repaglinide; acid-base properties; ionization macro- and microconstants; lipophilicity; solubility
( repaglinide; acid-base properties; ionization macro- and microconstants; lipophilicity; solubility )
Sažetak:
Potentiometric and spectrophotometric titrations were used for the determination of ionization behviour, lipophilicity and solubility profile of repaglinide. Acid-base equilibria were characterized by means of protonation macro- and microconstants using Target Factor Analysis of spectrophotometric data. Lipophilicity profiles were evaluated by determination of partition coefficients of neutral and ionized forms of repaglinide in biphasic octanol/water system. The intrinsic solubility of repaglinide were determined from the solubility data and temperature dependence of intrinsic solubilities were evaluated using van't Hoff equation.
Projekt / tema: 0125010
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TGX-4JDVNXT-2-15&_cdi=5266&_user=3875467&_pii=S0731708506001270&_origin=browse&_coverDate=06%2F07%2F2006&_sk=999589996&view=c&wchp=dGLzVtz-zSkzV&md5=6b3c8c81307480d8502dd8372e8c99cb&ie=/sdarticle.pdf
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGX-4JDVNXT-2&_user=3875467&_coverDate=06%2F07%2F2006&_rdoc=27&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info(%23toc%235266%232006%23999589996%23622950%23FLA%23display%23Volume)&_cdi=5266&_sort=d&_docanchor=&_ct=61&_acct=C000050661&_version=1&_urlVersion=0&_userid=3875467&md5=aa329a5f3c22b64f72dc2c0b01fe5468&searchtype=a
Broj citata:
Altmetric:
DOI: 10.1016/j.jpba.2006.01.056
URL cjelovitog teksta:
Google Scholar: Ionization, lipophilicity and solubility properties of repaglinide



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